Volume 1 Issue 1 | 2024 | View PDF
Paper Id: IJMSM-V1I1P105
doi: 10.71141/30485037/V1I1P105

Erythrina Indica Ethyl Acetate Extract Inhibits Diethyl Nitrosamine-Induced Developmental Toxicity via Changing the Notch Signalling Pathway in Zebrafish Embryos

Ram C, Vijay L, Soorya D

Citation:
Ram C, Vijay L, Soorya D, "Erythrina Indica Ethyl Acetate Extract Inhibits Diethyl Nitrosamine-Induced Developmental Toxicity via Changing the Notch Signalling Pathway in Zebrafish Embryos" International Journal of Multidisciplinary on Science and Management, Vol. 1, No. 1, pp. 21-24, 2024.

Abstract:
Diethyl nitrosamine (DEN), a potent liver carcinogen derived from secondary amines found in fertilizers and pesticides, has garnered attention due to its widespread presence in tiny amounts in food and water. It has the potential to induce cancer of the liver and digestive tract in living organisms. The tree Erythrina indica, also known as E. indica, possesses antioxidant and anti-inflammatory properties, and it may possibly have hepatoprotective effects. Because of their short reproductive cycles and translucent embryos, which make it easy to detect developmental toxicity, zebrafish embryos are ideal for creating pre-regulatory medications. We used the fish's embryos for this experiment. In addition to DEN, some of the embryos also got E. indica leaf extracts. By comparing the development of embryos exposed to DEN with those that had further treatment with E. indica leaves, we were able to demonstrate a possible protective effect against this carcinogen by lowering the toxicity of DEN in these embryos.

Keywords: Diethyl nitrosamine, Developmental toxicity, Zebrafish embryos.

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